Counteracting tinnitus by acoustic coordinated reset neuromodulation.
نویسندگان
چکیده
PURPOSE Subjective tinnitus is associated with pathologic enhanced neuronal synchronization. We used a model based desynchronization technique, acoustic coordinated reset (CR) neuromodulation, to specifically counteract tinnitus-related neuronal synchrony thereby inducing an unlearning of pathological synaptic connectivity and neuronal synchrony. METHODS In a prospective, randomized, single blind, placebo-controlled trial in 63 patients with chronic tonal tinnitus and up to 50 dB hearing loss we studied safety and efficacy of different doses of acoustic CR neuromodulation. We measured visual analogue scale and tinnitus questionnaire (TQ) scores and spontaneous EEG. RESULTS CR treatment was safe, well-tolerated and caused a significant decrease of tinnitus loudness and symptoms. Placebo treatment did not lead to any significant changes. Effects gained in 12 weeks of treatment persisted through a preplanned 4-week therapy pause and showed sustained long-term effects after 10 months of therapy: response, i.e. a reduction of at least 6 TQ points, was obtained in 75% of patients with a mean TQ reduction of 50% among responders. CR therapy significantly lowered tinnitus frequency and reversed the tinnitus related EEG alterations. CONCLUSION The CR-induced reduction of tinnitus and underlying neuronal characteristics indicates a new non-invasive therapy which might also be applicable to other conditions with neuronal hypersynchrony.
منابع مشابه
Rebuttal to reply by G. Rücker and G. Antes on Tass et al. "Counteracting tinnitus by acoustic coordinated reset neuromodulation", Restorative neurology and neuroscience Vol. 30(2), 2012.
We would like to thank Dr. Gerta Rücker and Prof. Gerd Antes for their interest in our article “Counteracting tinnitus by acoustic coordinated reset neuromodulation” and for their suggestions especially as the Cochrane collaboration has a long-standing track record for reviewing tinnitus therapies. Specifically, they found very limited evidence for efficacy of commonly used tinnitus therapies (...
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BACKGROUND There are growing technological advances in the development of sound-based methods for the treatment of tinnitus. Most of these methods intend to affect the speculated underlying neurological causes of tinnitus. Acoustic coordinated reset (CR) neuromodulation is one of them. A novel method that as of yet seems inadequately reviewed. PURPOSE To evaluate the current evidence on acous...
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ورودعنوان ژورنال:
- Restorative neurology and neuroscience
دوره 30 2 شماره
صفحات -
تاریخ انتشار 2012